firstly Sagarji, thank you so so much for your patience and also giving me an opportunity to read this case, it was a pleasure to research and learn through your chart…very unique combinations…I tried to gv background and logic as well so it can be used for further decoding if needed..
Firstly, Few points to keep in mind before we proceed to the conclusion –

Pending Prarabhdha karma (not the fixed karma) seen in fifth house, something you get from your own previous birth deads not some curse we carry from family tree or generations basis = Sun+Merc+Jup in 5th house

Sun has combusted Mercury and Jupiter (Sun signifies father)

Venus and moon in 6th house (moon signifies mother)

Venus also being your atmakaraka

Exalted planets – Sun, Moon, Mars,

Own signs placements – Venus and Rahu

Pushkar navamsa and pushkar bhagya – Mars, Ascendant, ketu where Mars and Ketu also in Pushkar Bhagya(good placements)

Retrograde planets to be notes – Saturn(Mula nakshatra 3rd pada karmic also in lagna so refers to why you are born), Neptune, Uranus and Pluto

With Rahu and Ketu taking in highest degrees of 27 in chart (Rahu mahadasha since March 2017 has aggravated the situation)

However you carry pending karma as per your fifth house placement –

Sun (father) is combusting (Mercury (Siblings & neighbours) and Jupiter (inner contentment and joy of human and ability to reason things and situations in life)

Moon (Mother) is in 6th house (house of illnesses, debts, seva, job, and court cases) (placement where a person will constantly feel unsatisfied with the conditions of life)

Luckily your moon and venus are both placed together in Venus nakshatra rohini which is favourable nakshatra but placements is 6th house which could be better if different house.

Now about pending karma, this is not family curse but as per combinations I believe – in your past birth you had planned a few things that you wanted to do before your death which are incomplete still and for that reason you have been given another chance, looking at saturn and uranus in 1st house where saturn is retro (note:mars, merc, sun in 8th house in D9)

1 thing to note is that lord Rama had Rahu in 3rd house as well, though he had to go to vanvaasa due to step mother intervention and promise by his dad to step mother however his step siblings were good to him because of Jupiter placements.

I am unaware of what dreams you could not fulfill in your previous birth but in this birth you can surely do it becasue of retro saturn in lagna, only activate/ energize your jupiter, Venus, saturn and Mars, they will show you through meditation or japa about your life purpose. Specially hanuman ji he can help here to identify the purpose.

In your past life because of your fathers pressure you have changed or left guru and also isolated your siblings becasue that time you gave in to your fathers pressure and could not show confidence and were fearful hence you isolated so in this birth their soul is negative towards you. (Rahu in 3rd house)

However you can change or improvise this situation as it is 6th house karma so it is not fixed karma and can be changed. Would you like to do any simple in house remedies / changes in schedule to help improve this situation, let me know. Just simple remedies and within 90 days you can start seeing changes in the situation.